I don't think MLS is anywhere near the level of EPL. I suppose a few of the top tier teams of MLS could compete with some of the lower level teams of the EPL, like West Ham, Sheffield, and Fulham. But they couldn't hold a candle to the likes of Man U, Chelsea, or Liverpool. But I also think Lalas knows this, and I think he is just trying to stir the pot and generate some interest in the league. I would say his remarks are working seeing as I've been reading about his remarks everywhere and a lot of people have been discussing it, including those that don't call themselves soccer fans.
I am one that hopes that MLS gets better and maybe one day it'll be up there eith EPL and la Liga, but it definitely isn't right now.