The obvious big improvement on the Bills is their DL. That can cause the Jets less then dominant OL some problems. Though overall, Shonn Greene and the Jets have been able to effectively run the ball on the Bills in the past. And I still think they will be effective enough to allow Sanchez to use his play action magic, to connect vertically down the field. Especially if Keller is healthy and playing.
The Bills won't be running very effectively against this Jets D.
Jets DL and blitz sub packages will cause Fitz some really big problems. I see Jets winning the turnover battle. He's going to get picked off by Jets secondary once or twice for sure.
Landry and Bell should be able to do a good job policing the middle of the field.
IMO, Jets can score 23-24 points and win this game.