Luck and Freeman.
Indianapolis is not an effective team on the ground and Houston's secondary has been awful for a month now. If Chad Henne and Cecil Shorts can wreak havoc in the Houston secondary, I'm fairly certain Andrew Luck will be able to with Reggie Wayne, T.Y. Hilton and his assortment of Tight Ends.
As for Freeman .. he's got the Saints pitiful pass defense. That's all you need.